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1-甲基-1H-2-氰基甲基-咪唑并[4,5-b]吡啶的合成与某些反应。所得化合物的抑菌活性。

Synthesis and some reactions of 1-methyl-1H-2-cyanomethyl-imidazo[4,5-b]pyridine. Tuberculostatic activity of obtained compounds.

作者信息

Bukowski L, Janowiec M

机构信息

Department of Organic Chemistry, Medical Academy, Gdańsk, Poland.

出版信息

Pharmazie. 1990 Dec;45(12):904-7.

PMID:2129248
Abstract

1-Methyl-1H-2-cyanomethyl-imidazo[4,5-b]pyridine was synthesized and the reactivity of its CN and --CH2--groups was investigated. 5 H-Dipyrido[1,2-a: 3',2'd]imidazole derivatives were also prepared. Some of the obtained compounds were screened for their tuberculostatic activity.

摘要

合成了1-甲基-1H-2-氰甲基-咪唑并[4,5-b]吡啶，并研究了其氰基和亚甲基的反应活性。还制备了5H-二吡啶并[1,2-a:3',2'-d]咪唑衍生物。对部分所得化合物进行了抑菌活性筛选。

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