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咪唑并[4,5 - b]吡啶 - 7 - 羧酸及其一些具有预期抗结核活性的衍生物的合成。

Synthesis of imidazo [4,5-b] pyridine-7-carboxylic acid and some of its derivatives with expected antituberculous activity.

作者信息

Bukowski L

出版信息

Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):767-72.

PMID:6791143
Abstract

The title acid 2 and its methyl ester 3, hydrazide 4, hydrazone 5, amide 6, nitrile 7, amidoxime 8 and thioamide 9 have been obtained. As a result of methylation of 2 with diazomethane N-CH3 derivatives of these compounds 10-17 were obtained and their structure was preliminary established as 3-CH3 compounds. Some of the obtained compounds were investigated for their tuberculostatic activity.

摘要

已制得标题酸2及其甲酯3、酰肼4、腙5、酰胺6、腈7、偕胺肟8和硫代酰胺9。用重氮甲烷使2甲基化,得到这些化合物的N-CH₃衍生物10 - 17,并初步确定其结构为3-CH₃化合物。对所得到的一些化合物进行了抗结核活性研究。

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