1-甲基-1H-2-咪唑并[4,5-b]吡啶羧酸及其一些具有疑似抗结核活性的衍生物。

1-Methyl-1H-2-imidazo[4,5-b]pyridinecarboxylic acid and some of its derivatives with suspected antituberculotic activity.

作者信息

Bukowski L, Janowiec M

机构信息

Department of Organic Chemistry, Medical University of Gdańsk, Warsaw, Poland.

出版信息

Pharmazie. 1996 Jan;51(1):27-30.

Abstract

2-Hydroxymethyl-1-methyl-1H-imidazo[4,5-b]pyridine was obtained and its oxidation was carried out. 1-Methyl-1H-2-imidazo[4,5-b]pyridinecarboxylic acid, its methyl ester, amide, nitrile, thioamide, amidoxime, hydrazide and hydrazidehydrazones were synthesized. Willgerodt-Kindler reaction of 1,2-dimethyl-1H-imidazo[4,5-b]pyridine was investigated. Some of the obtained compounds were tested for antituberculotic activity.

摘要

制得2-羟甲基-1-甲基-1H-咪唑并[4,5-b]吡啶并对其进行了氧化反应。合成了1-甲基-1H-咪唑并[4,5-b]吡啶羧酸、其甲酯、酰胺、腈、硫代酰胺、偕胺肟、酰肼及酰肼腙。研究了1,2-二甲基-1H-咪唑并[4,5-b]吡啶的威尔格罗德特-金德勒反应。对部分所得化合物进行了抗结核活性测试。

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