Yao Chang, Storey Dan, Webster Thomas J
Division of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
Int J Nanomedicine. 2007;2(3):487-92.
Bioactive coatings are in high demand to increase the functions of cells for numerous medical devices. The objective of this in vitro study was to characterize osteoblast (bone-forming cell) adhesion on several potential orthopedic polymeric materials (specifically, polyetheretherketone, ultra-high molecular weight polyethylene, and polytetrafluoroethylene) coated with either titanium or gold using a novel Ionic Plasma Deposition process which creates a surface-engineered nanostructure (with features below 100 nm). Results demonstrated that compared to currently-used titanium and uncoated polymers, polymers coated with either titanium or gold using Ionic Plasma Deposition significantly increased osteoblast adhesion. Qualitative cell morphology results supported quantitative adhesion results as increased osteoblast cell spreading was observed on coated polymers compared to uncoated polymers. In this manner, this in vitro study strongly suggests that Ionic Plasma Deposition should be further studied for creating nanometer surface features on a wide variety of materials to enhance osteoblast functions necessary for orthopedic applications.
为了增强众多医疗设备中细胞的功能，生物活性涂层的需求量很大。这项体外研究的目的是使用一种新型离子等离子体沉积工艺，来表征成骨细胞（骨形成细胞）在几种潜在的骨科聚合物材料（具体为聚醚醚酮、超高分子量聚乙烯和聚四氟乙烯）上的粘附情况，该工艺会产生一种表面工程纳米结构（特征尺寸低于100纳米），这些材料要么涂覆有钛，要么涂覆有金。结果表明，与目前使用的钛和未涂层的聚合物相比，使用离子等离子体沉积工艺涂覆有钛或金的聚合物显著提高了成骨细胞的粘附力。定性的细胞形态学结果支持了定量粘附结果，因为与未涂层的聚合物相比，在涂覆的聚合物上观察到成骨细胞的铺展增加。通过这种方式，这项体外研究有力地表明，对于在各种材料上创建纳米表面特征以增强骨科应用所需的成骨细胞功能，离子等离子体沉积工艺应进一步开展研究。
