Smith Lester J, Swaim John S, Yao Chang, Haberstroh Karen M, Nauman Eric A, Webster Thomas J
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Int J Nanomedicine. 2007;2(3):493-9.
There are more than 30,000 orthopedic implant revision surgeries necessary each year in part due to poor implant fixation with juxtaposed bone. A further emphasis on the current problems associated with insufficient bone implant performance is the fact that many patients are receiving hip implants earlier in life, remaining active older, and that the human lifespan is continuously increasing. Collectively, it is clear that there is a strong clinical need to improve implant performance through proper, prolonged fixation. For these reasons, the objective of the present in vitro study was to improve the performance of titanium (Ti), one of the most popular orthopedic implant materials. Accordingly, the proliferative response of osteoblasts (bone-forming cells) on novel nanostructured Ti/PLGA (poly-lactic-co-glycolic acid) composites was examined. This study showed that nano-topography can be easily applied to Ti (through anodization) and porous PLGA (through NaOH chemical etching) to enhance osteoblast cell proliferation which may lead to better orthopedic implant performance. This straight forward application of nano-topography on current bone implant materials represents a new direction in the design of enhanced biomaterials for the orthopedic industry.
每年有超过30000例骨科植入物翻修手术是必要的，部分原因是植入物与相邻骨骼的固定不佳。当前与骨植入物性能不足相关问题的另一个重点是，许多患者在年轻时就接受了髋关节植入物，在老年时仍保持活跃，而且人类寿命在不断延长。总体而言，显然临床上迫切需要通过适当、持久的固定来提高植入物性能。出于这些原因，本体外研究的目的是改善钛（Ti）的性能，钛是最常用的骨科植入材料之一。因此，研究了成骨细胞（骨形成细胞）对新型纳米结构Ti/PLGA（聚乳酸-乙醇酸共聚物）复合材料的增殖反应。这项研究表明，纳米拓扑可以很容易地应用于钛（通过阳极氧化）和多孔PLGA（通过NaOH化学蚀刻），以增强成骨细胞的增殖，这可能会带来更好的骨科植入物性能。纳米拓扑在当前骨植入材料上的这种直接应用代表了骨科行业增强生物材料设计的一个新方向。
