Friedman R M, Costa J C, Ramseur J M, Meyers M W, Jay F T, Chang E H
J Infect Dis. 1976 Jun;133 Suppl:A43-50. doi: 10.1093/infdis/133.supplement_2.a43.
In AKR mouse cells chronically infected with a murine leukemia virus, treatment with interferon for nine days resulted in sustained inhibition of extracellular production of murine leukemia virus but no inhibition of viral intracellular p30 antigen or of reverse transcriptase. Removal of interferon resulted in rapid reversal of these effects. Interferon-treated mouse L-cells were infected with high multiplicities of vesicular stomatitis virus or herpes simplex virus type 1. Infectious virus and intracellular viral antigen were rapidly eliminated from the interferon-treated cultures infected with herpes simplex virus. In cultures infected with vesicular stomatitis virus, titers of virus remained low in interferon-treated cells, but after about two weeks they rose rapidly and the cultures were destroyed. If treatment with interferon was reinstituted as late as nine days after primary infection, infectious vesicular stomatitis virus was eliminated, and there was no evidence for survival of the viral genome in these cultures. In the cultures infected with murine leukemia virus, inhibition of production of virus by treatment with interferon was possible, but the viral genome was not eliminated. In cells acutely infected with vesicular stomatitis virus or herpes simplex virus, however, the viral genomes were apparently eliminated from cultures treated with interferon.
在长期感染鼠白血病病毒的AKR小鼠细胞中，用干扰素处理九天可导致鼠白血病病毒细胞外产生受到持续抑制，但对病毒细胞内p30抗原或逆转录酶没有抑制作用。去除干扰素会导致这些效应迅速逆转。用高倍感染复数的水疱性口炎病毒或1型单纯疱疹病毒感染经干扰素处理的小鼠L细胞。在感染单纯疱疹病毒的经干扰素处理的培养物中，感染性病毒和细胞内病毒抗原迅速被清除。在感染水疱性口炎病毒的培养物中，经干扰素处理的细胞中病毒滴度保持较低水平，但约两周后迅速上升，培养物被破坏。如果在初次感染后九天这么晚的时候重新开始用干扰素处理，感染性水疱性口炎病毒会被清除，并且在这些培养物中没有病毒基因组存活的证据。在感染鼠白血病病毒的培养物中，用干扰素处理抑制病毒产生是可能的，但病毒基因组未被清除。然而，在急性感染水疱性口炎病毒或单纯疱疹病毒的细胞中，病毒基因组显然从经干扰素处理的培养物中被清除。
