抑制慢性感染的AKR细胞中鼠白血病病毒的产生：干扰素的一种新作用。
Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon.
作者信息
Friedman R M, Ramseur J M
出版信息
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3542-4. doi: 10.1073/pnas.71.9.3542.
Abstract
Treatment of AKR cells that had spontaneously become procedures of a murine leukemia virus with a partially purified mouse interferon (> 5 x 10(7) international mouse reference units per mg of protein) inhibited endogenous virus production. This inhibitory effect decreased over a 72-hr period in a manner similar to interferon-induced antiviral activity directed against vesicular stomatitis virus in AKR cells. Despite the inhibitory effect of interferon on infectious murine leukemia virus and viral reverse transcriptase (RNA-dependent DNA polymerase) titers in the culture fluids, intracellular levels of viral groups-specific antigens were significantly increased. These results suggest that interferon treatment in AKR cells inhibited the assembly or release of the virus.
摘要
用部分纯化的小鼠干扰素（每毫克蛋白质>5×10⁷国际小鼠参考单位）处理已自发成为鼠白血病病毒产生程序的AKR细胞，可抑制内源性病毒的产生。这种抑制作用在72小时内以类似于干扰素诱导的针对AKR细胞中水泡性口炎病毒的抗病毒活性的方式降低。尽管干扰素对培养液中感染性鼠白血病病毒和病毒逆转录酶（RNA依赖性DNA聚合酶）滴度有抑制作用，但细胞内病毒群特异性抗原水平却显著增加。这些结果表明，干扰素处理AKR细胞可抑制病毒的组装或释放。
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