van Ravenswaaij-Arts C M, Hopman J C, Kollée L A, van Amen J P, Stoelinga G B, van Geijn H P
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Early Hum Dev. 1991 Dec;27(3):187-205. doi: 10.1016/0378-3782(91)90194-8.
To investigate the influence of maturational and physiological factors on heart rate variability in spontaneously breathing very preterm infants (n = 29) a multiparametric study was performed during the first 3 days of life in infants born at a gestational age below 33 weeks. Four times a day, RR-intervals, respiration curve and rate, transcutaneously measured blood gases and observed body movements were recorded while the infants were asleep. All data were stored simultaneously in a micro-computer. Non-invasively measured blood pressure and patency of the ductus arteriosus were documented as well. Four sets of short- (STV) and long term variability (LTV) indices were calculated. Both STV and LTV appeared to be significantly influenced by conceptional and postnatal age in the appropriate for gestational age infants. LTV was influenced by the behavioural state and body movements. During state coincidence 2 ('active sleep') LTV was influenced by respiratory rate and the variations in transcutaneous PO2. An effect of blood pressure or ductus patency could not be demonstrated.
为研究成熟度和生理因素对自主呼吸的极早产儿（n = 29）心率变异性的影响，对孕周小于33周的婴儿在出生后第1天至第3天进行了一项多参数研究。每天4次，在婴儿睡眠时记录RR间期、呼吸曲线和频率、经皮测量的血气以及观察到的身体运动。所有数据同时存储在一台微型计算机中。还记录了无创测量的血压和动脉导管通畅情况。计算了四组短期（STV）和长期变异性（LTV）指标。对于适于胎龄的婴儿，STV和LTV似乎都受到孕龄和出生后年龄的显著影响。LTV受行为状态和身体运动的影响。在状态2（“主动睡眠”）期间，LTV受呼吸频率和经皮PO2变化的影响。未证明血压或动脉导管通畅情况有影响。
