van Ravenswaaij-Arts C M, Hopman J C, Kollée L A, van Amen J P, Stoelinga G B, van Geijn H P
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Early Hum Dev. 1991 Dec;27(3):207-21. doi: 10.1016/0378-3782(91)90195-9.
In a multi-parametric study the influence of pathological neonatal conditions on heart rate variability was investigated in 60 preterm infants born at a gestational age below 33 weeks. Measurements were performed during the first 3 days of life. Four times a day, RR-intervals, respiration curve and rate, transcutaneously measured blood gases and observed body movements were recorded while the infants were asleep. All data were stored simultaneously in a micro-computer. Severity of respiratory distress syndrome (RDS), patency of ductus arteriosus and periventricular haemorrhage were documented as well. Four sets of short- (STV) and long-term variability (LTV) indices were calculated. Severe RDS was associated with a significant decrease in LTV. The influence of RDS on LTV persisted after correction for conceptional age, postnatal age, behavioural state and variations in respiratory rate and in transcutaneous PO2. Infants with a symptomatic patent ductus arteriosus had lower LTV than controls with the same severity of RDS. STV was predominantly influenced by postnatal and conceptional age, and tended to be lower in infants with periventricular haemorrhage.
在一项多参数研究中，对60名孕周小于33周的早产儿进行了研究，以探讨病理性新生儿状况对心率变异性的影响。测量在出生后的头3天进行。每天4次，在婴儿睡眠时记录RR间期、呼吸曲线和频率、经皮测量的血气以及观察到的身体运动。所有数据同时存储在一台微型计算机中。还记录了呼吸窘迫综合征（RDS）的严重程度、动脉导管通畅情况和脑室周围出血情况。计算了四组短期（STV）和长期变异性（LTV）指标。严重RDS与LTV显著降低有关。在对孕龄、出生后年龄、行为状态以及呼吸频率和经皮氧分压的变化进行校正后，RDS对LTV的影响仍然存在。有症状性动脉导管未闭的婴儿的LTV低于具有相同RDS严重程度的对照组。STV主要受出生后和孕龄的影响，脑室周围出血的婴儿的STV往往较低。
