Campbell L J, Crews C M
Department of Molecular, Cellular and Developmental Biology, Yale University, P. O. Box 208103, New Haven, CT 06520-8103, USA.
Cell Mol Life Sci. 2008 Jan;65(1):73-9. doi: 10.1007/s00018-007-7433-z.
Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.
在有尾两栖动物肢体被截肢后，截肢平面周围的表皮细胞迁移以愈合伤口。由此产生的伤口表皮（WE）诱导再生过程，导致芽基形成、细胞分裂，并最终重新形成一个新的肢体。尽管其在肢体再生起始中起核心作用，但关于伤口表皮如何形成却知之甚少。在此，我们讨论伤口表皮形成的各种模型以及支持每种模型的实验数据。
