Rosenau A, Labigne A, Escande F, Courcoux P, Philippon A
Laboratoire de Microbiologie, Groupe Hospitalier Boucicaut-Vaugirard, Paris, France.
Antimicrob Agents Chemother. 1991 Nov;35(11):2419-22. doi: 10.1128/AAC.35.11.2419.
A Pasteurella multocida human isolate was resistant to beta-lactams because of production of ROB-1 beta-lactamase. The beta-lactamase was encoded by a 4.3-kb plasmid closely related to that of a Pasteurella bovine strain, as shown by Sau3A restriction profile and hybridization with a plasmid probe containing the blaROB-1 gene.
一株多杀巴斯德氏菌的人类分离株因产生ROB-1β-内酰胺酶而对β-内酰胺类抗生素耐药。如Sau3A酶切图谱以及与含有blaROB-1基因的质粒探针杂交所示，该β-内酰胺酶由一个与巴斯德氏菌牛源菌株的质粒密切相关的4.3 kb质粒编码。
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