Pancewicz Sławomir A, Rutkowski Ryszard, Rutkowski Krzysztof, Zajkowska Joanna M, Kondrusik Maciej
Akademia Medyczna w Białymstoku, Klinika Chorób Zakaźnych i Neuroinfekcji.
Pol Merkur Lekarski. 2007 Aug;23(134):141-4.
Lyme borreliosis (Lyme disease) is the most prevalent tick-borne disease caused by spirochaetes of the Borrelia species complex. Arthritis is one of the common manifestations of B. burgdorferi infection. The pathomechanism of articular changes in Lyme arthritis has not yet been elucidated. Histopathological studies of synovia and immunological changes are similar to rheumatoid arthritis. In the early stage of inflammation B. burgdorferi interact with polynuclear granulocytes and epithelial cells, triggering production of reactive oxygen species, lipid peroxidation products and other inflammatory mediators. The imbalance between anabolic and catabolic processes in inflamed joints results in the progressive destruction of articular cartilage and disintegration of extracellular matrix. Molecular mimicry between OspA (outer surface protein A) and adhesion molecule LFA-1alpha seems to be responsible for chronic arthritis.
莱姆病螺旋体病（莱姆病）是由伯氏疏螺旋体属复合体的螺旋体引起的最常见的蜱传疾病。关节炎是伯氏疏螺旋体感染的常见表现之一。莱姆关节炎关节变化的发病机制尚未阐明。滑膜的组织病理学研究和免疫变化与类风湿关节炎相似。在炎症早期，伯氏疏螺旋体与多形核粒细胞和上皮细胞相互作用，引发活性氧、脂质过氧化产物和其他炎症介质的产生。炎症关节中合成代谢和分解代谢过程之间的失衡导致关节软骨的渐进性破坏和细胞外基质的解体。外表面蛋白A（OspA）与黏附分子LFA-1α之间的分子模拟似乎是慢性关节炎的原因。
