Haba T, Sarna S K
Department of Surgery, Medical College of Wisconsin.
Am J Physiol. 1993 Feb;264(2 Pt 1):G261-71. doi: 10.1152/ajpgi.1993.264.2.G261.
We investigated the mechanisms of regulation of gastroduodenal emptying of solid meals by gastropyloroduodenal contractions in six conscious dogs. The spatial and temporal parameters of gastropyloroduodenal contractions were correlated with the rate of gastroduodenal emptying. The rate of gastroduodenal emptying exhibited a significant positive correlation with the 1) mean frequency of corporeal and antral contractions; 2) mean frequency, amplitude, duration, and area under pyloric contractions; 3) percentage of contractions that propagated in the distal duodenum, and the mean distance of their propagation; 4) percentage of contractions that propagated within the stomach, including the pylorus; 5) percentage of contractions that propagated from the antrum or the pylorus to the proximal duodenum; and 6) ratio of the mean frequency of contractions in the antrum to that in the proximal or the distal duodenum during the entire period of gastroduodenal emptying. The major factors that exhibited a significant negative correlation with gastroduodenal emptying were the total number, amplitude, duration, and area under contractions in the whole duodenum during the entire period of gastroduodenal emptying. We conclude that the antropyloroduodenal contractions, acting as a peristaltic pump, are a major factor in the regulation of gastric emptying of solid meals. The propagating contractions in the distal duodenum promote gastric emptying by rapidly removing the chyme from this area, whereas the nonpropagated contractions in the duodenum may provide a mechanical resistance to gastric emptying.
我们在6只清醒犬中研究了胃幽门十二指肠收缩对固体食物胃十二指肠排空的调节机制。胃幽门十二指肠收缩的空间和时间参数与胃十二指肠排空率相关。胃十二指肠排空率与以下各项呈显著正相关：1）胃体和胃窦收缩的平均频率；2）幽门收缩的平均频率、幅度、持续时间和收缩面积；3）在十二指肠远端传播的收缩百分比及其平均传播距离；4）在胃内（包括幽门）传播的收缩百分比；5）从胃窦或幽门向十二指肠近端传播的收缩百分比；6）在整个胃十二指肠排空期间，胃窦收缩平均频率与十二指肠近端或远端收缩平均频率的比值。与胃十二指肠排空呈显著负相关的主要因素是在整个胃十二指肠排空期间，整个十二指肠收缩的总数、幅度、持续时间和收缩面积。我们得出结论，作为蠕动泵的胃幽门十二指肠收缩是调节固体食物胃排空的主要因素。十二指肠远端的传播性收缩通过迅速清除该区域的食糜促进胃排空，而十二指肠内的非传播性收缩可能对胃排空提供机械阻力。
