Höök-Nikanne J
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Digestion. 1991;50(2):92-8. doi: 10.1159/000200745.
To investigate the effect of alcohol consumption on the risk of Helicobacter pylori infection, standardized questionnaires on drinking habits were used to interview 451 patients, whose H. pylori status was determined both by culture and serology. Reported alcohol consumption did not increase the risk of H. pylori infection (a 1.0 odds ratio, CI95 0.6-1.6). However, when the patients were divided into two age-groups, those under 35 years who reported to use alcohol seemed to have a slightly higher risk of H. pylori infection (a 3.3 odds ratio CI95 0.9-12.2) compared to those over 35 years (a 1.0 odds ratio, CI95 0.5-2.2). This phenomenon did not reach statistical significance. The type of alcohol consumed did not affect the age-adjusted risk of H. pylori infection. If pathologically defined chronic gastritis was found, the risk for H. pylori was high (a 26.7 odds ratio, CI95 12.1-59.0, for those under 35 years, and a 12.8 odds ratio, CI95 6.7-24.3, for those over 35 years of age.
为研究饮酒对幽门螺杆菌感染风险的影响，使用关于饮酒习惯的标准化问卷对451例患者进行访谈，这些患者的幽门螺杆菌感染状况通过培养和血清学两种方法确定。报告的饮酒情况并未增加幽门螺杆菌感染风险（比值比为1.0，95%置信区间为0.6 - 1.6）。然而，当将患者分为两个年龄组时，报告饮酒的35岁以下患者相比35岁以上患者似乎有稍高的幽门螺杆菌感染风险（比值比为3.3，95%置信区间为0.9 - 12.2），而35岁以上患者的比值比为1.0，95%置信区间为0.5 - 2.2。这一现象未达到统计学显著性。所饮用酒精的类型并未影响经年龄调整后的幽门螺杆菌感染风险。如果发现有病理定义的慢性胃炎，幽门螺杆菌感染风险很高（35岁以下患者的比值比为26.7，95%置信区间为12.1 - 59.0；35岁以上患者的比值比为12.8，95%置信区间为6.7 - 24.3）。
