肥胖青少年的胃饥饿素和瘦素水平。与体脂及胰岛素抵抗的关系。
Ghrelin and leptin levels in obese adolescents. Relationship with body fat and insulin resistance.
作者信息
Stylianou Charilaos, Galli-Tsinopoulou Assimina, Farmakiotis Dimitrios, Rousso Israel, Karamouzis Michael, Koliakos George, Nousia-Arvanitakis Sanda
机构信息
4th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Greece.
出版信息
Hormones (Athens). 2007 Oct-Dec;6(4):295-303. doi: 10.14310/horm.2002.1111025.
OBJECTIVE
Ghrelin and leptin levels are influenced by body fat (BF%), pubertal stage and possibly insulin resistance (IR). The aim of our study was: 1) To compare fasting ghrelin and leptin levels between obese and non-obese, adolescents, 2) to investigate possible correlations of these hormones with BF %, as well as IR.
DESIGN
Twenty obese insulin resistant (IR) adolescents, twenty obese non IR (NIR) and fifteen healthy non-obese, age-matched adolescents were studied. In all participants, height, weight, body mass index (BMI) and BF % were measured. Fasting glucose, insulin, ghrelin and leptin levels were determined. IR was assessed using HOMA-IR index.
RESULTS
BMI, BF %, insulin and HOMA-IR values were positively correlated with leptin and negatively with ghrelin levels. A negative correlation between circulating leptin and ghrelin levels was found. A suggestive positive correlation between leptin levels and BF %, independent of BMI, was also observed (P=0.075). Ghrelin levels were significantly correlated with insulin levels and HOMA-IR, independent of BMI (P=0.077).
CONCLUSIONS
Obesity and IR may play an important role in the release of ghrelin as well as in the negative correlation between ghrelin and leptin.
目的
胃饥饿素和瘦素水平受体脂（BF%）、青春期阶段影响，可能还受胰岛素抵抗（IR）影响。我们研究的目的是：1）比较肥胖和非肥胖青少年空腹胃饥饿素和瘦素水平；2）研究这些激素与BF%以及IR之间可能存在的相关性。
设计
对20名肥胖胰岛素抵抗（IR）青少年、20名肥胖非胰岛素抵抗（NIR）青少年以及15名年龄匹配的健康非肥胖青少年进行了研究。测量了所有参与者的身高、体重、体重指数（BMI）和BF%。测定了空腹血糖、胰岛素、胃饥饿素和瘦素水平。使用稳态模型评估胰岛素抵抗（HOMA-IR）指数评估IR。
结果
BMI、BF%、胰岛素和HOMA-IR值与瘦素呈正相关，与胃饥饿素水平呈负相关。发现循环瘦素和胃饥饿素水平之间呈负相关。还观察到瘦素水平与BF%之间存在提示性正相关，且独立于BMI（P=0.075）。胃饥饿素水平与胰岛素水平和HOMA-IR显著相关，且独立于BMI（P=0.077）。
结论
肥胖和IR可能在胃饥饿素的释放以及胃饥饿素与瘦素之间的负相关中起重要作用。
Zotero 插件