超重/肥胖女性的食欲及激素（瘦素、胃饥饿素和胰岛素）与静息代谢率的关联：一项病例对照研究。

The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case-control study.

作者信息

Hajishizari Sara, Imani Hossein, Mehranfar Sanaz, Saeed Yekaninejad Mir, Mirzababaei Atieh, Clark Cain C T, Mirzaei Khadijeh

机构信息

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

出版信息

BMC Nutr. 2022 Apr 29;8(1):37. doi: 10.1186/s40795-022-00531-w.

DOI:10.1186/s40795-022-00531-w

PMID:35484608

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9052687/

Abstract

OBJECTIVE

Low resting metabolic rate (RMR), as a risk factor for weight gain and obesity, can be influenced by many factors. Empirical research has confirmed the role of appetite and related hormones in obesity and energy intake. This study aimed to investigate the relationship between appetite and related hormones in overweight or obese Iranian women with normal and hypo RMR.

METHODS

This case-control study was conducted on 42 Iranian adult women (21 cases, and 21 controls), aged 18-48 years. An impedance body analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. The Flint questionnaire was used to assess appetite, dietary intake, and physical activity were assessed by FFQ and IPAQ questionnaires respectively, and ELISA kits were used to assess leptin, ghrelin, and insulin hormones.

RESULTS

The results of the study demonstrated a negative association between ghrelin hormone level (β = -0.34, 95%CI = -61.70,-3.86, P-value = 0.027) and RMR, and a positive association between insulin hormone level (β = 0.48, 95%CI = 9.38-34.35, P-value = 0.001) and RMR. Also, results of the appetite questionnaire showed that, in general, both appetite (β = 0.32, 95%CI = -0.10-2.99 P-value = 0.044) and hunger variable (β = 0.30, 95%CI = 0.04-5.87, P-value = 0.047) have a positive association with RMR. There was no significant association between leptin levels and RMR.

CONCLUSION

It is evident that appetite and related hormones have a potential role in promoting a normal RMR.

摘要

目的

低静息代谢率（RMR）作为体重增加和肥胖的一个风险因素，会受到多种因素的影响。实证研究已证实食欲及相关激素在肥胖和能量摄入中的作用。本研究旨在调查正常和低RMR的超重或肥胖伊朗女性的食欲与相关激素之间的关系。

方法

本病例对照研究对42名年龄在18至48岁的伊朗成年女性（21例病例和21例对照）进行。使用阻抗体成分分析仪获取身体成分，并使用间接热量计评估RMR。采用弗林特问卷评估食欲，分别通过FFQ和IPAQ问卷评估饮食摄入和身体活动，并使用ELISA试剂盒评估瘦素、胃饥饿素和胰岛素激素。

结果

研究结果表明，胃饥饿素水平与RMR呈负相关（β = -0.34，95%CI = -61.70，-3.86，P值 = 0.027），胰岛素激素水平与RMR呈正相关（β = 0.48，95%CI = 9.38 - 34.35，P值 = 0.001）。此外，食欲问卷结果显示，总体而言，食欲（β = 0.32，95%CI = -0.10 - 2.99，P值 = 0.044）和饥饿变量（β = 0.30，95%CI = 0.04 - 5.87，P值 = 0.047）均与RMR呈正相关。瘦素水平与RMR之间无显著关联。