一日三次服用速释型哌甲酯对注意力缺陷多动障碍儿童睡眠的急性影响。
Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder.
作者信息
Corkum Penny, Panton Rachel, Ironside Sarah, Macpherson Marilyn, Williams Tracey
机构信息
Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H4J1.
出版信息
J Pediatr Psychol. 2008 May;33(4):368-79. doi: 10.1093/jpepsy/jsm106. Epub 2007 Dec 3.
OBJECTIVE
To determine the impact of immediate release Ritalin, given three times a day, on sleep quality and quantity in medication-naïve, newly diagnosed children with attention-deficit/hyperactivity disorder (ADHD).
METHODS
Children (aged 6-12) rigorously diagnosed with ADHD (n = 21) underwent multiple measurement assessments (i.e., actigraphy, sleep diary, and questionnaires) during a 1-week baseline and then during a 3-week blinded randomized medication trial.
RESULTS
Although the medication was effective in reducing ADHD symptoms, analyses of actigraphy and sleep diary data found statistically and clinically significant changes in the children's total sleep time and sleep onset latency in the medication compared to the no medication conditions. No effects on sleep were found based on the sleep questionnaire.
CONCLUSIONS
Physicians and parents are encouraged to closely monitor children's sleep when treating ADHD with stimulant medication.
目的
确定每日三次服用速释型利他林对未经药物治疗、新诊断的注意力缺陷多动障碍（ADHD）儿童睡眠质量和睡眠时间的影响。
方法
严格诊断为ADHD的6至12岁儿童（n = 21）在1周的基线期以及随后为期3周的双盲随机药物试验期间接受了多次测量评估（即活动记录仪、睡眠日记和问卷调查）。
结果
尽管药物治疗在减轻ADHD症状方面有效，但对活动记录仪和睡眠日记数据的分析发现，与未用药情况相比，用药期间儿童的总睡眠时间和入睡潜伏期在统计学和临床上均有显著变化。基于睡眠问卷未发现对睡眠有影响。
结论
鼓励医生和家长在用兴奋剂药物治疗ADHD时密切监测儿童的睡眠情况。
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