Moss Jo, Magiati Iliana, Charman Tony, Howlin Patricia
Department of Community Health Sciences, St George's, University of London, London, UK.
J Autism Dev Disord. 2008 Jul;38(6):1081-91. doi: 10.1007/s10803-007-0487-9. Epub 2007 Dec 6.
This study examined the stability of scores on the ADI-R from pre-school to elementary school age in children with autism spectrum disorders (ASD). Participants were 35 children who, at T1, all had a clinical diagnosis of ASD. On initial assessment (mean age 3.5 years; SD 0.6 years), all met ADI-R algorithm criteria for autism. ADI-R assessments were repeated at follow up (FU; mean age 10.5 years; SD 0.8 years). Changes in ADI-R total, domain and ADI-R algorithm item scores were assessed. Twenty-eight children continued to score above the ADI-R cut-off for autism at FU, although significant decreases in ADI-R domain and item scores were also found. In conclusion while classification of children according to ADI-R criteria generally remained stable between pre-school and elementary school age, many children demonstrated significant improvements in symptom severity.
本研究考察了自闭症谱系障碍(ASD)儿童从学前到小学阶段的孤独症诊断访谈修订版(ADI-R)评分的稳定性。研究对象为35名儿童,在T1时,他们均被临床诊断为ASD。在初次评估时(平均年龄3.5岁;标准差0.6岁),所有儿童均符合ADI-R自闭症诊断标准。在随访时(FU;平均年龄10.5岁;标准差0.8岁)重复进行ADI-R评估。评估了ADI-R总分、领域分和ADI-R诊断标准项目得分的变化。28名儿童在随访时的ADI-R得分仍高于自闭症诊断临界值,不过也发现ADI-R领域分和项目得分有显著下降。总之,虽然根据ADI-R标准对儿童的分类在学前到小学阶段总体保持稳定,但许多儿童的症状严重程度有显著改善。