补骨脂酚及其衍生物的合成与结构-免疫抑制活性关系
Synthesis and structure-immunosuppressive activity relationships of bakuchiol and its derivatives.
作者信息
Chen Hongli, Du Xiaolong, Tang Wei, Zhou Yu, Zuo Jianping, Feng Huijin, Li Yuanchao
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Road Zu Chong Zhi, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
出版信息
Bioorg Med Chem. 2008 Mar 1;16(5):2403-11. doi: 10.1016/j.bmc.2007.11.054. Epub 2007 Nov 28.
PMID:18063371
Abstract
A series of derivatives of bakuchiol were synthesized and tested in vitro for their cytotoxicity, and inhibition of T cell proliferation and B cell proliferation. The data obtained provided preliminary structure-activity relationships of the compounds as immunosuppressive activity.
摘要
合成了一系列补骨脂酚衍生物，并在体外测试了它们的细胞毒性以及对T细胞增殖和B细胞增殖的抑制作用。所获得的数据提供了这些化合物作为免疫抑制活性的初步构效关系。
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