Cady Jormain
The Radiation Oncology Department, The Virginia Mason Medical Center, Seattle, WA, USA.
Clin J Oncol Nurs. 2007 Dec;11(6):875-80. doi: 10.1188/07.CJON.875-880.
Significant weight loss and resultant malnutrition in patients undergoing radiotherapy for head and neck carcinomas are recognized and preventable clinical concerns. Morbidity related to weight loss during treatment may include dehydration, hospitalization, compromised treatment efficacy, and reduced quality of life and may impact survival. Malnutrition effects on wound healing may prolong recovery following treatment and increase the risk of morbidity for those undergoing subsequent salvage surgery. Multiple interventions have been implemented to help ameliorate the impact of treatment on weight loss and nutritional status, including the use of percutaneous endoscopic gastrostomy (PEG) tubes. The value of prophylactic PEG tube placement at treatment initiation increasingly is being recognized, and evidence suggests that patients experience better outcomes. Criteria for patient selection have not been defined completely, and a great deal of variation in clinical practice exists, contributing to underuse of this supportive intervention. According to a literature review, patients who require therapeutic PEG tube placement in response to significant weight loss during treatment suffer greater morbidity than patients who receive PEG tubes prophylactically. Understanding patient-, tumor-, and treatment-related risk factors to systematically identify patients most likely to benefit from prophylactic PEG tube placement is an important aspect of nursing care.
头颈部癌放疗患者出现显著体重减轻及由此导致的营养不良是公认的且可预防的临床问题。治疗期间与体重减轻相关的发病率可能包括脱水、住院、治疗效果受损、生活质量下降,并且可能影响生存。营养不良对伤口愈合的影响可能会延长治疗后的恢复时间,并增加接受后续挽救性手术患者的发病风险。已经实施了多种干预措施来帮助减轻治疗对体重减轻和营养状况的影响,包括使用经皮内镜下胃造口术(PEG)管。在治疗开始时预防性放置PEG管的价值越来越受到认可,并且有证据表明患者会有更好的结果。患者选择标准尚未完全明确,临床实践中存在很大差异,导致这种支持性干预措施使用不足。根据一项文献综述,因治疗期间体重显著减轻而需要治疗性放置PEG管的患者比预防性接受PEG管的患者发病率更高。了解患者、肿瘤和治疗相关的风险因素,以系统地识别最有可能从预防性PEG管放置中受益的患者,是护理工作的一个重要方面。