Chien Hsiu-Wen, Chen Ying-Yuan, Chen Yen-Lun, Cheng Chi-Hui, Lin Jui-Che
Department of Chemical and Material Engineering, National Kaohsiung University of Science and Technology Kaohsiung Taiwan.
Department of Chemical Engineering, National Cheng Kung University Tainan Taiwan
RSC Adv. 2019 Mar 4;9(13):7257-7265. doi: 10.1039/c9ra00094a. eCollection 2019 Mar 1.
This work describes the synthesis of novel antimicrobial agents consisting of -halamine and dual quaternary ammonium with different alkyl chain lengths and their antimicrobial applications for PET nonwovens. The antimicrobial agents were grafted onto PET nonwovens esterification with a crosslinker, 1,2,3,4-butanetetracarboxylic acid (BTCA). The cyclic amide structure in the antimicrobial agents could be easily converted to -halamine after immersion in a diluted chlorine bleach solution. Variations in surface chemical composition of the modified PET nonwovens were examined by XPS. Antimicrobial activities of the nonwovens/fabrics were tested against (Gram-positive) and (Gram-negative) strains. Systematic investigation showed the antibacterial activities were dependent upon the alkyl chain length. The synergism of -halamine and dual quaternary ammonium could lead to significant antimicrobial activity with inactivation of up to 90% of and after 10 minute contact. This work suggested that the novel composite biocides with -halamine and dual quaternary ammonium groups and the associated surface modification methods could be of use for further developing antimicrobial nonwoven applications.
这项工作描述了由含卤胺和具有不同烷基链长度的双季铵盐组成的新型抗菌剂的合成及其在聚酯非织造布上的抗菌应用。通过与交联剂1,2,3,4-丁烷四羧酸（BTCA）进行酯化反应，将抗菌剂接枝到聚酯非织造布上。抗菌剂中的环状酰胺结构在浸入稀释的含氯漂白剂溶液后可轻松转化为含卤胺。通过XPS检测改性聚酯非织造布表面化学成分的变化。测试了非织造布/织物对革兰氏阳性菌和革兰氏阴性菌菌株的抗菌活性。系统研究表明，抗菌活性取决于烷基链长度。含卤胺和双季铵盐的协同作用可导致显著的抗菌活性，接触10分钟后，可使高达90%的革兰氏阳性菌和革兰氏阴性菌失活。这项工作表明，具有含卤胺和双季铵盐基团的新型复合杀菌剂以及相关的表面改性方法可用于进一步开发抗菌非织造布应用。
