Sun Jian-Fan, Lin Xiuping, Zhou Xue-Feng, Wan Junting, Zhang Tianyu, Yang Bin, Yang Xian-Wen, Tu Zhengchao, Liu Yonghong
1] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, People's Republic of China [2] School of Environment, Jiangsu University, Zhenjiang, People's Republic of China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
J Antibiot (Tokyo). 2014 Jun;67(6):451-7. doi: 10.1038/ja.2014.24. Epub 2014 Apr 2.
Five alkenyl phenol and benzaldehyde derivatives, pestalols A-E (1-5), as well as seven known compounds (6-12), were isolated from endophytic fungus Pestalotiopsis sp. AcBC2 derived from the Chinese mangrove plant Aegiceras corniculatum. Their structures were determined by spectroscopic analyses. Compounds 2 and 3 showed cytotoxicity against a panel of 10 tumor cell lines. Compounds 1-5, 8, 9, 11, and 12 showed inhibitory activities against Influenza A virus subtype (H3N2) and Swine Flu (H1N1) viruses. Compound 2 also showed inhibitory activity against tuberculosis.
从中国红树林植物桐花树（Aegiceras corniculatum）内生真菌Pestalotiopsis sp. AcBC2中分离得到了五种链烯基苯酚和苯甲醛衍生物，即pestalols A - E（1 - 5），以及七种已知化合物（6 - 12）。通过光谱分析确定了它们的结构。化合物2和3对一组10种肿瘤细胞系显示出细胞毒性。化合物1 - 5、8、9、11和12对甲型流感病毒亚型（H3N2）和猪流感（H1N1）病毒表现出抑制活性。化合物2对结核病也显示出抑制活性。
