Li Li-Ya, Ding Yi, Groth Ingrid, Menzel Klaus-Dieter, Peschel Gundela, Voigt Kerstin, Deng Zi-Wei, Sattler Isabel, Lin Wen-Han
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):775-80. doi: 10.1080/10286020802031106.
Two new pyrrole alkaloids, N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide (1) and N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide (2), and a new indole derivative (3aR,8aR)-3a-acetoxyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indol (3) were isolated, together with ( - )-3a-hydroxyfuroindoline, (3aR,8aS)-1-acetyl-1,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indol-3a-ol, and N-acetyltryptamine A, from an endophytic ascomycetous fungus, Fusarium incarnatum (HKI00504), which was isolated from the mangrove plant Aegiceras corniculatum. The structures of compounds 1-3 were determined on the basis of extensive spectroscopic data analyses.
从红树植物桐花树分离得到的内生子囊菌镰刀菌（HKI00504）中，分离出两种新的吡咯生物碱，N-[4-(2-甲酰基-5-羟甲基-吡咯-1-基)-丁基]-乙酰胺（1）和N-[5-(2-甲酰基-5-羟甲基-吡咯-1-基)-戊基]-乙酰胺（2），以及一种新的吲哚衍生物(3aR,8aR)-3a-乙酰氧基-1,2,3,3a,8,8a-六氢吡咯并-[2,3-b]吲哚（3），同时还分离出了(-)-3a-羟基呋喃吲哚啉、(3aR,8aS)-1-乙酰基-1,3,3a,8,8a-六氢吡咯并-[2,3-b]吲哚-3a-醇和N-乙酰色胺A。化合物1-3的结构是基于广泛的光谱数据分析确定的。
