Komili Suzanne, Silver Pamela A
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02119, USA.
Nat Rev Genet. 2008 Jan;9(1):38-48. doi: 10.1038/nrg2223.
Genome-scale analyses have allowed us to progress beyond studying gene expression at the level of individual components of a given process by providing global information about functional connections between genes, mRNAs and their regulatory proteins. Such analyses have greatly increased our understanding of the interplay between different events in gene regulation and have highlighted previously unappreciated functional connections, including coupling between nuclear and cytoplasmic processes. Genome-wide approaches have also revealed extensive coordination within regulatory levels, such as the organization of transcription factors into regulatory motifs. Overall, these studies enhance our understanding of how the many components of the eukaryotic cell function as a system to allow both coordination and versatility in gene expression.
基因组规模分析使我们能够超越在给定过程的单个组成部分水平上研究基因表达，通过提供有关基因、mRNA及其调控蛋白之间功能联系的全局信息。此类分析极大地增进了我们对基因调控中不同事件之间相互作用的理解，并突出了以前未被认识到的功能联系，包括核过程与细胞质过程之间的偶联。全基因组方法还揭示了调控水平内的广泛协调，例如转录因子组织成调控基序。总体而言，这些研究增进了我们对真核细胞的众多组成部分如何作为一个系统发挥作用以实现基因表达的协调和多样性的理解。
