Lapizco-Encinas Blanca H, Rito-Palomares Marco
Departamento de Ingeniería Química, Centro de Biotecnología, Tecnológico de Monterrey, Monterrey, NL, México.
Electrophoresis. 2007 Dec;28(24):4521-38. doi: 10.1002/elps.200700303.
Dielectrophoresis (DEP) is a nondestructive electrokinetic mechanism with great potential for the manipulation of bioparticles. DEP is the movement of particles induced by polarization effects in nonuniform electric fields. Since the 1960s, this technique has been successfully used for the manipulation of microbioparticles, such as microorganisms. Moreover, due to the advances in microfabrication techniques, that allowed progressively smaller microstructures to be constructed, DEP can now be used for the manipulation of nanobioparticles. The first research studies on the DEP of nanobioparticles started in the 1990s. Since then, many research groups have carried out outstanding work with DEP of nanobioparticles such as macromolecules, virus, and spores. However, the need of a critical report that integrates these findings is evident. The aim of the present review is to depict the state-of-the-art on the use of DEP for the separation of nanobioparticles and the potential trends of novel applications of this technique. This review compiles and analyzes the significant findings obtained by many researchers. This publication is intended to provide the reader with state-of-the-art information on many research studies focused on DEP to handle nanobioparticles.
介电泳（DEP）是一种具有巨大潜力的非破坏性电动机制，可用于操控生物粒子。介电泳是指在非均匀电场中由极化效应引起的粒子运动。自20世纪60年代以来，该技术已成功用于操控微生物粒子，如微生物。此外，由于微纳加工技术的进步，使得能够构建越来越小的微结构，现在介电泳可用于操控纳米生物粒子。关于纳米生物粒子介电泳的首批研究始于20世纪90年代。从那时起，许多研究团队在纳米生物粒子（如大分子、病毒和孢子）的介电泳方面开展了出色的工作。然而，显然需要一份整合这些研究结果的重要报告。本综述的目的是描述介电泳用于分离纳米生物粒子的最新进展以及该技术新应用的潜在趋势。本综述汇编并分析了许多研究人员取得的重要发现。本出版物旨在为读者提供有关众多聚焦于介电泳处理纳米生物粒子的研究的最新信息。
