基于微纳加工平台利用非均匀电场对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进行操控、采样及灭活的研究综述

Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review.

作者信息

Mantri Devashish, Wymenga Luutzen, van Turnhout Jan, van Zeijl Henk, Zhang Guoqi

机构信息

Department Biomedical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands.

Department Microelectronics, Delft University of Technology, 2628 CD Delft, The Netherlands.

出版信息

Micromachines (Basel). 2023 Jan 29;14(2):345. doi: 10.3390/mi14020345.

DOI:10.3390/mi14020345

PMID:36838044

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9967285/

Abstract

Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically.

摘要

利用电场捕获、分析和灭活微生物的微型设备在概念、设计和应用方面存在差异。文献中已广泛描述了利用电场来操纵和灭活细菌及单细胞生物。相比之下，此类电场对病毒的影响尚不十分清楚。本综述探讨了将现有用于操纵和灭活较大病毒及细菌的方法应用于诸如严重急性呼吸综合征冠状病毒2（SARS-CoV-2）等较小病毒的可能性。它还概述了理论背景。这些研究结果可用于实施新想法并设定实验参数，以优化对SARS-CoV-2进行电操纵、采样和灭活。