用于生物医学应用的基于微流体的电驱动粒子操控技术。
Microfluidic-based electrically driven particle manipulation techniques for biomedical applications.
作者信息
Wang Jiulin, Cui Xinyuan, Wang Wei, Wang Junhao, Zhang Quili, Guo Xiaonan, Liang Yanfeng, Lin Shujin, Chu Bingfeng, Cui Daxiang
机构信息
Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai JiaoTong University Shanghai 200240 PR China
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025 PR China.
出版信息
RSC Adv. 2025 Jan 3;15(1):167-198. doi: 10.1039/d4ra05571c. eCollection 2025 Jan 2.
Microfluidic chips exhibit unique advantages in both economy and rapidity, particularly for the separation and detection of biomolecules. In this review, we first introduced the mechanisms of several electrically driven methods, such as electrophoresis, dielectrophoresis, electro-wetting and electro-rotation. We then discussed in detail the application of these methods in nucleic acid analysis, protein manipulation and cell treatment. In addition, we outlined the considerations for material selection, manufacturing processes and structural design of microfluidic chips based on electrically driven mechanisms.
微流控芯片在经济性和快速性方面都具有独特优势，尤其适用于生物分子的分离和检测。在本综述中，我们首先介绍了几种电驱动方法的机制，如电泳、介电泳、电润湿和电旋转。然后我们详细讨论了这些方法在核酸分析、蛋白质操作和细胞处理中的应用。此外，我们概述了基于电驱动机制的微流控芯片在材料选择、制造工艺和结构设计方面的考虑因素。
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