Rohrer Ursula, Kunz Eva M Kulik, Lenkeit Krystyna, Schaffner Willi, Meyer Jürg
Institute of Preventive Dentistry and Oral Microbiology, School of Dental Medicine, University of Basel, Switzerland.
Schweiz Monatsschr Zahnmed. 2007;117(11):1126-31.
Extracts or alkaloids isolated from Mahonia aquifolium exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and protozoa. In this study the bacteriostatic and bacteriocidal activities of a M. aquifolium extract and two of its major alkaloids, berberine chloride and oxyacanthine sulphate, were tested in vitro against nine different oral bacteria. Minimum inhibitory concentrations were in the range from < or = 0.0031% to 0.1993% for the M. aquifolium extract, from 0.002% to > 0.125% for berberine chloride, and from 0.0156% to > 0.0625% for oxyacanthine sulphate. The values for the minimum bactericidal concentrations were in the same range, indicating that the test substances most probably acted in a bactericidal manner. The most susceptible bacterium against all three test substances was Porphyromonas gingivalis.
从阔叶十大功劳中分离出的提取物或生物碱对革兰氏阳性菌、革兰氏阴性菌、真菌和原生动物具有抗菌活性。在本研究中，对阔叶十大功劳提取物及其两种主要生物碱（氯化小檗碱和硫酸刺檗碱）的抑菌和杀菌活性进行了体外测试，受试对象为九种不同的口腔细菌。阔叶十大功劳提取物的最低抑菌浓度范围为≤0.0031%至0.1993%，氯化小檗碱为0.002%至＞0.125%，硫酸刺檗碱为0.0156%至＞0.0625%。最低杀菌浓度值在相同范围内，表明受试物质很可能以杀菌方式起作用。对所有三种受试物质最敏感的细菌是牙龈卟啉单胞菌。
