Desandes Emmanuel, Berger Claire, Tron Isabelle, Demeocq François, Bellec Stéphanie, Blouin Pascale, Casagranda Léonie, De Lumley Lionel, Freycon Fernand, Goubin Aurélie, Le Gall Edouard, Sommelet Danièle, Lacour Brigitte, Clavel Jacqueline
National Registry of Childhood Solid Tumours, CHU Nancy, Université Henri Poincaré 1, Faculté de Médecine 9, Avenue de la Forêt de Haye, BP 184, F-54505 Vandoeuvre-Lès-Nancy cedex, France.
Eur J Cancer. 2008 Jan;44(2):205-15. doi: 10.1016/j.ejca.2007.11.016.
The aim of this study was to describe the overall survival after childhood cancer in France using follow-up data from regional population-based registries. The survival of children (aged under 15 years) diagnosed with a cancer during 1990-1999 was analysed. For all cancers, the survivals were, respectively, 90.3% [89.4-91.3] at 1-year, 75.2% [73.8-76.6] at 5 years and 72.2% [70.7-73.7] at 10 years. During the 1990s, the average improvement in the 5-year survival was +1.2% per year. Adjusted for gender, age, area of residence and stage, children with cancer diagnosed between 1995 and 1999 had a 0.80 reduced risk of dying compared with those whose cancer had been diagnosed between 1990 and 1994. The increase of survival at the population level reflects a global improvement in childhood cancer care. The Paediatric Registries, in association with the French Society of Childhood Cancer, are now collecting data to quantify on a national basis the other events, at least relapse and second cancers.
本研究旨在利用基于地区人口登记处的随访数据，描述法国儿童癌症患者的总生存率。分析了1990年至1999年期间被诊断患有癌症的儿童（15岁以下）的生存率。对于所有癌症，1年生存率分别为90.3%[89.4 - 91.3]，5年生存率为75.2%[73.8 - 76.6]，10年生存率为72.2%[70.7 - 73.7]。在20世纪90年代，5年生存率的平均年改善率为+1.2%。经性别、年龄、居住地区和分期调整后，1995年至1999年期间被诊断患有癌症的儿童与1990年至1994年期间被诊断患有癌症的儿童相比，死亡风险降低了0.80。人群水平上生存率的提高反映了儿童癌症护理的总体改善。儿科登记处与法国儿童癌症协会合作，目前正在收集数据，以便在全国范围内量化其他事件，至少是复发和二次癌症。
