Emeric Erik E, Brown Joshua W, Leslie Melanie, Pouget Pierre, Stuphorn Veit, Schall Jeffrey D
Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology,Vanderbilt University, Nashville, Tennessee, USA.
J Neurophysiol. 2008 Feb;99(2):759-72. doi: 10.1152/jn.00896.2006. Epub 2007 Dec 12.
We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at approximately 70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.
我们描述了在执行扫视抑制任务的猕猴前扣带回皮质（ACC）中记录到的颅内局部场电位（LFP）。在大约70%的记录位点，最显著的特征是错误后比奖励正确试验后的负极性更强。这种负极性在无奖励的正确试验中也会出现。视觉目标诱发的LFP极化程度要小得多，且扫视前的微弱调制不足以控制扫视的启动。当扫视被取消时，LFP调制随着与根据取消概率估计的注视转移和保持神经元的共同激活相对应的反应冲突大小而略有下降。然而，后续试验中的反应时间调整与单个试验中的LFP极性无关。这些结果提供了明确的证据，表明猕猴ACC中的LFP携带了与错误和反馈相关而非与冲突相关的信号。在猕猴ACC中发现性能监测场电位，在人类的事件相关电位和功能性脑成像研究与非人类灵长类动物的神经生理学研究之间架起了一座桥梁。
