Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7817, USA.
J Neurophysiol. 2010 Sep;104(3):1523-37. doi: 10.1152/jn.01001.2009. Epub 2010 Jul 21.
We describe intracranial local field potentials (LFPs) recorded in the supplementary eye field (SEF) of macaque monkeys performing a saccade countermanding task. The most prominent feature at 90% of the sites was a negative-going polarization evoked by a contralateral visual target. At roughly 50% of sites a negative-going polarization was observed preceding saccades, but in stop signal trials this polarization was not modulated in a manner sufficient to control saccade initiation. When saccades were canceled in stop signal trials, LFP modulation increased with the inferred magnitude of response conflict derived from the coactivation of gaze-shifting and gaze-holding neurons. At 30% of sites, a pronounced negative-going polarization occurred after errors. This negative polarity did not appear in unrewarded correct trials. Variations of response time with trial history were not related to any features of the LFP. The results provide new evidence that error-related and conflict-related but not feedback-related signals are conveyed by the LFP in the macaque SEF and are important for identifying the generator of the error-related negativity.
我们描述了在执行扫视抑制任务的猕猴的补充眼区（SEF）中记录的颅内局部场电位（LFPs）。在 90%的位点上，最显著的特征是由对侧视觉目标诱发的负向极化。在大约 50%的位点上，在扫视前观察到负向极化，但在停止信号试验中，这种极化的调制不足以控制扫视的开始。当扫视在停止信号试验中被取消时，LFPs 的调制会随着来自注视转移和注视保持神经元的共同激活的推断的反应冲突程度而增加。在 30%的位点上，在错误后出现明显的负向极化。这种负极性不会出现在无奖励的正确试验中。反应时间随试验历史的变化与 LFPs 的任何特征都没有关系。结果提供了新的证据，表明与错误相关和与冲突相关但与反馈无关的信号是由猴 SEF 中的 LFPs 传递的，这对于识别错误相关负性的发生器很重要。
