Prabhu Krishnananda, Bhat Gopalakrishna P
Department of Biochemistry, Kasturba Medical College, Manipal - 576 104, Karnataka, India.
J Cancer Res Ther. 2007 Jul-Sep;3(3):167-8. doi: 10.4103/0973-1482.37411.
We conducted a study wherein serum total glutathione-s-transferase levels were measured in patients (n = 27) with various stages of biopsy proven oral cancer (squamous cell carcinoma) and age and sex matched healthy human volunteers (n=10). In all patients with oral cancer, serum total glutathione-s-transferase was measured before the onset of treatment. There was a significant increase in serum total glutathione-s-transferase levels in patients with stage IV oral cancer as compared to stage II (P = 0.001) and stage III (P = 0.002) oral cancer. This shows that alterations in serum total Glutathione-s-transferase levels may have a role in cancer progression.
我们开展了一项研究，测定了经活检证实患有不同阶段口腔癌（鳞状细胞癌）的患者（n = 27）以及年龄和性别匹配的健康人类志愿者（n = 10）的血清总谷胱甘肽 - S - 转移酶水平。在所有口腔癌患者中，于治疗开始前测定血清总谷胱甘肽 - S - 转移酶。与II期（P = 0.001）和III期（P = 0.002）口腔癌患者相比，IV期口腔癌患者的血清总谷胱甘肽 - S - 转移酶水平显著升高。这表明血清总谷胱甘肽 - S - 转移酶水平的改变可能在癌症进展中起作用。
