Nakachi Sawako, Nagasaki Akitoshi, Owan Isoko, Uchihara Teruhito, Fujita Jiro, Ohshima Koichi, Miyagi Takashi, Taira Tamiko, Taira Naoya, Takasu Nobuyuki
Dept. of Endocrinology and Metabolism, Internal Medicine, University of the Ryukyus School of Medicine.
Gan To Kagaku Ryoho. 2007 Dec;34(13):2279-82.
Primary extranodal involvement of Hodgkin lymphoma (HL) is rare. We report two HL patients presenting with exclusive or predominant lung involvement. In both cases, the results of transbronchial and/or CT-guided lung needle biopsy were indicative of granulomatous disease. Eventually, lymph node biopsy specimens revealed HL with nodular sclerosis type and lymphocyte-rich type, respectively. There were no specific symptoms, laboratory and imaging findings for pulmonary HL. A histological examination was required to confirm the diagnosis. Lung biopsy techniques such as transbronchial or percutaneous biopsy may be insufficient to allow diagnosis of HL. Pulmonary HL should be included in the differential diagnosis of lung involvement, even when the pathological evaluation of nonspecific inflammation was made from the biopsied specimens.
霍奇金淋巴瘤（HL）的原发性结外受累较为罕见。我们报告了两名以单纯或主要肺部受累为表现的HL患者。在这两个病例中，经支气管和/或CT引导下的肺穿刺活检结果均提示为肉芽肿性疾病。最终，淋巴结活检标本分别显示为结节硬化型和富于淋巴细胞型HL。肺部HL没有特异性症状、实验室检查和影像学表现。需要进行组织学检查以确诊。经支气管或经皮活检等肺活检技术可能不足以诊断HL。即使从活检标本进行了非特异性炎症的病理评估，肺部HL也应纳入肺部受累的鉴别诊断中。
