Rollins A M, Ung-Arunyawee R, Chak A, Wong R C, Kobayashi K, Sivak M V, Izatt J A
Opt Lett. 1999 Oct 1;24(19):1358-60. doi: 10.1364/ol.24.001358.
We report on the design and initial clinical experience with a real-time endoscopic optical coherence tomography (EOCT) imaging system. The EOCT unit includes a high-speed optical coherence tomography interferometer, endoscope-compatible catheter probes, and real-time data capture and display hardware and software. Several technological innovations are introduced that improve EOCT efficiency and performance. In initial clinical studies using the EOCT system, the esophagus, stomach, duodenum, ileum, colon, and rectum of patients with normal endoscopic findings were examined. In these initial investigations, EOCT imaging clearly delineated the substructure of the mucosa and submucosa in several gastrointestinal organs; microscopic structures such as glands, blood vessels, pits, villi, and crypts were also observed.
我们报告了一种实时内镜光学相干断层扫描（EOCT）成像系统的设计及初步临床经验。EOCT设备包括一个高速光学相干断层扫描干涉仪、与内窥镜兼容的导管探头，以及实时数据采集和显示硬件及软件。引入了多项技术创新以提高EOCT的效率和性能。在使用EOCT系统的初步临床研究中，对内镜检查结果正常的患者的食管、胃、十二指肠、回肠、结肠和直肠进行了检查。在这些初步研究中，EOCT成像清晰地勾勒出了多个胃肠道器官黏膜和黏膜下层的亚结构；还观察到了腺体、血管、小凹、绒毛和隐窝等微观结构。
