Nishimori Isao, Kohsaki Takuhiro, Onishi Saburo, Shuin Taro, Kohsaki Shino, Ogawa Yasuhiro, Matsumoto Manabu, Hiroi Makoto, Hamano Hideaki, Kawa Shigeyuki
Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku.
Intern Med. 2007;46(24):1983-9. doi: 10.2169/internalmedicine.46.0452. Epub 2007 Dec 17.
Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [18F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.
最近，自身免疫性胰腺炎（AIP）已有多种胰腺外表现的报道，且IgG4阳性细胞浸润至受累器官。我们在此报告两例前列腺炎病例。一例见于典型AIP患者，另一例未出现AIP的任何临床表现。两例患者血清IgG4水平均升高。前列腺组织学检查显示实质细胞部分或完全被纤维化及大量IgG4阳性细胞浸润所取代。两例患者前列腺均见[18F]氟脱氧葡萄糖显著摄取。在AIP病例中，类固醇治疗后摄取完全消失。这些病例中观察到的结果提示，前列腺炎的病理机制与先前认为的AIP机制相似，即IgG4相关性自身免疫性前列腺炎。
