Sinha Tuhin K, Khatib-Shahidi Sheerin, Yankeelov Thomas E, Mapara Khubaib, Ehtesham Moneeb, Cornett D Shannon, Dawant Benoit M, Caprioli Richard M, Gore John C
Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA.
Nat Methods. 2008 Jan;5(1):57-9. doi: 10.1038/nmeth1147. Epub 2007 Dec 16.
We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
我们已经开发出一种方法,能够以动物特异性方式,将全小鼠头部的空间分辨基质辅助激光解吸/电离成像质谱(MALDI IMS)离子图像的三维体积重建与来自其他模态的高分辨率图像进行整合。这种方法使我们能够根据磁共振成像提供的相应体内数据,分析MALDI IMS数据中的蛋白质组学图谱。