Jönsson Thomas J, Lowther W Todd
Center for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Subcell Biochem. 2007;44:115-41. doi: 10.1007/978-1-4020-6051-9_6.
Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry.
硫氧还蛋白和硒蛋白是半胱氨酸亚磺酸还原酶，可选择性地还原或修复真核生物中典型的2-半胱氨酸过氧化物酶的过度氧化形式。因此，这些酶在过氧化物介导的细胞信号传导和细胞防御机制的调节中起关键作用。硫氧还蛋白的独特结构有助于进入过氧化物酶的活性位点并形成新的硫化学。
