肺炎、肺癌及结核性胸膜炎患者血浆和胸腔积液中的白细胞介素-1β（IL-1β）、白细胞介素6（IL-6）及肿瘤坏死因子（TNF）
Interleukin -1beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor (TNF) in plasma and pleural fluid of pneumonia, lung cancer and tuberculous pleuritis.
作者信息
Ilonidis G, Parapanisiou E, Anogeianaki A, Giavazis I, Theofilogiannakos E K, Tsekoura P, Kidonopoulou K, Trakatelli Chr, Polimenidis Z, Conti P, Anogianakis G
机构信息
Fourth Internal Medicine Clinic, Hippokration Hospital, Aristotle University of Thessaloniki, Greece.
出版信息
J Biol Regul Homeost Agents. 2006 Jan-Jun;20(1-2):41-6.
Interleukins IL-1beta, IL-6 and TNF are increased in plasma of patients with severe infections and septic shock. Our objective was the evaluation of IL-1beta, IL-6 and TNF in plasma and exudates of pleural fluid and their contribution to the diagnosis. We studied 44 patients, 27 men and 17 women with mean age 66.81 +/- 11.75 years; 16 with pneumonia and parapneumonic effusion, 14 with primary lung cancer and pleural effusion and 14 with tuberculous pleuritis. We measured IL-1beta, IL-6 and TNF in serum and pleural fluid with ELISA. In patients with pneumonia and parapneumonic effusion the mean value of IL-1beta IL-6 and TNF in plasma was 9.05, 19.24 and 21.34 pg/ml and in pleural fluid 10.34, 32.19 and 25.30 pg/ml. In patients with lung cancer the mean values of IL-1beta, IL-6 and TNF were 5.33, 11.74 and 11.51 pg/ml and 6.70, 13.13, 20.89 pg/ml, respectively. In those with tuberculous pleuritis the respective mean values were 10.33, 49.94, 21.27 pg/ml and 14, 56.59, 23.58 pg/ml. In conclusion, IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status.
白细胞介素IL - 1β、IL - 6和肿瘤坏死因子（TNF）在严重感染和脓毒症休克患者的血浆中水平升高。我们的目的是评估IL - 1β、IL - 6和TNF在血浆以及胸腔积液渗出液中的水平及其对诊断的贡献。我们研究了44例患者，其中男性27例，女性17例，平均年龄66.81±11.75岁；16例患有肺炎并伴有类肺炎性胸腔积液，14例患有原发性肺癌并伴有胸腔积液，14例患有结核性胸膜炎。我们采用酶联免疫吸附测定法（ELISA）测量血清和胸腔积液中的IL - 1β、IL - 6和TNF。患有肺炎并伴有类肺炎性胸腔积液的患者，血浆中IL - 1β、IL - 6和TNF的平均值分别为9.05、19.24和21.34 pg/ml，胸腔积液中分别为10.34、32.19和25.30 pg/ml。肺癌患者中，IL - 1β、IL - 6和TNF的平均值分别为5.33、11.74和11.51 pg/ml，胸腔积液中分别为6.70、13.13、20.89 pg/ml。患有结核性胸膜炎的患者，相应的平均值分别为10.33、49.94、21.27 pg/ml，胸腔积液中分别为14、56.59、23.58 pg/ml。总之，发现IL - 1β和IL - 6在血浆和结核性胸腔积液中升高，表明存在炎症状态。
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