开始高效抗逆转录病毒治疗（HAART）后麻风发病率增加：免疫重建疾病的一种表现

Increased incidence of leprosy following HAART initiation: a manifestation of the immune reconstitution disease.

作者信息

Couppié Pierre, Domergue Valérie, Clyti Emmanuel, El Guedj Myriam, Vaz Tania, Sainte-Marie Dominique, Marty Christian, Nacher Mathieu

机构信息

Service de Dermatologie, Institut Guyanais de Dermatologie Tropicale, French Guiana.

出版信息

AIDS. 2009 Jul 31;23(12):1599-600. doi: 10.1097/QAD.0b013e32832bb5b7.

DOI:10.1097/QAD.0b013e32832bb5b7

PMID:19487911

Abstract

A retrospective cohort study was conducted to determine whether the incidence of leprosy varied with the duration of antiretroviral therapy (ART). Between 1992 and 2006, seven cases of leprosy were observed. The incidence of leprosy in untreated patients was 0.7 per 1000 person-years, 13 per 1000 person-years in persons receiving HAART for more than 3 months and 0.9 per 1000 person-years for persons receiving HAART for more than 3 months. The adjusted hazard ratio was 18.5 (95% confidence interval, 1.6-217) with P = 0.02. In tropical areas where HAART is increasingly available, physicians should be aware of the possibility of incident leprosy shortly after HAART initiation.

摘要

开展了一项回顾性队列研究，以确定麻风发病率是否随抗逆转录病毒疗法（ART）疗程而变化。1992年至2006年期间，观察到7例麻风病例。未接受治疗患者的麻风发病率为每1000人年0.7例，接受高效抗逆转录病毒治疗（HAART）超过3个月的患者为每1000人年13例，接受HAART超过3个月的患者为每1000人年0.9例。调整后的风险比为18.5（95%置信区间为1.6 - 217），P = 0.02。在越来越容易获得HAART的热带地区，医生应意识到在开始HAART后不久发生麻风的可能性。