Franzini C
Laboratorio Centrale, Ospedale di Rho, Milano.
Ann Ist Super Sanita. 1991;27(3):359-63.
The basis for the achievement and the control of accuracy in routine testing is represented by a hierarchy of methods. Different materials are used for transferring accuracy and for monitoring traceability. In these two operations, unreliable results may be obtained by using different materials (e.g. clinical specimens and reference materials) when matrix-sensitive methods are being used, as is frequently the case with routine methods. Intermediate-level (reference) methods may help to bridge the gap between the highest and the lowest levels, by using clinical specimens for method comparisons. If non-commutable materials are used for calibration and control of routine methods, these should have system specific values, assigned with an appropriate experimental design, including appropriate use of clinical specimens. Setting up networks of reference laboratories to implement and run reference systems on an ongoing basis, appears to be the practical pathway to accuracy. Improvements should be directed to lowering the matrix-sensitivity of routine methods and increasing the commutability of reference materials.
常规检测中实现准确性及控制准确性的基础由一系列方法构成。不同材料用于传递准确性和监测可追溯性。在这两项操作中，当使用对基质敏感的方法时（常规方法经常如此），使用不同材料（如临床标本和参考材料）可能会得到不可靠的结果。中级（参考）方法可通过使用临床标本进行方法比较，来帮助弥合最高和最低水平之间的差距。如果将不可互换材料用于常规方法的校准和控制，则这些材料应具有系统特定值，并通过适当的实验设计来赋值，包括适当使用临床标本。建立参考实验室网络以持续实施和运行参考系统，似乎是实现准确性的切实途径。改进应着眼于降低常规方法的基质敏感性并提高参考材料的互换性。
