Calame Kathryn
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Immunity. 2007 Dec;27(6):825-7. doi: 10.1016/j.immuni.2007.11.010.
Vigorito et al. (2007) report (in this issue of Immunity) that B cells require microRNA (miR)-155 for normal production of isotype-switched, high-affinity antibodies and for a memory response. They identify transcriptional regulator Pu.1 as a functionally important target of miR-155 in B cells.
维戈里托等人（2007年）（在本期《免疫》杂志中）报道，B细胞正常产生同种型转换的高亲和力抗体以及产生记忆反应需要微小RNA（miR）-155。他们确定转录调节因子Pu.1是B细胞中miR-155在功能上的重要靶点。
