气道平滑肌中的干细胞：最新进展
Stem cells in airway smooth muscle: state of the art.
作者信息
Murphy Jaime, Summer Ross, Fine Alan
机构信息
The Pulmonary Center, R-304, 715 Albany Street, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Proc Am Thorac Soc. 2008 Jan 1;5(1):11-4. doi: 10.1513/pats.200704-052VS.
Abstract
Very little is known regarding the function, origin, and turnover of airway smooth muscle (ASM). In this article, we discuss the embryological development of ASM, and provide information regarding candidate mesenchymal ASM progenitor cell populations specifically in relation to airway remodeling. This review also highlights the current limitations in studying ASM biology, and underscores the need for novel molecular tools and markers that will refine our understanding of this cell type in lung homeostasis and disease.
摘要
关于气道平滑肌（ASM）的功能、起源和更新，我们所知甚少。在本文中，我们讨论了ASM的胚胎发育，并提供了有关候选间充质ASM祖细胞群的信息，特别是与气道重塑相关的信息。这篇综述还强调了目前在研究ASM生物学方面的局限性，并强调需要新的分子工具和标记物，以完善我们对这种细胞类型在肺稳态和疾病中的理解。
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