全视野数字乳腺摄影中的计算机辅助检测：系列检查中的敏感性和可重复性

Computer-aided detection in full-field digital mammography: sensitivity and reproducibility in serial examinations.

作者信息

Kim Seung Ja, Moon Woo Kyung, Cho Nariya, Cha Joo Hee, Kim Sun Mi, Im Jung-Gi

机构信息

Department of Radiology, Konkuk University Hospital, Seoul, Korea.

出版信息

Radiology. 2008 Jan;246(1):71-80. doi: 10.1148/radiol.2461062072.

DOI:10.1148/radiol.2461062072

PMID:18096530

Abstract

PURPOSE

To retrospectively evaluate the sensitivity and reproducibility of a computer-aided detection (CAD) system applied to serial digital mammograms obtained in women with breast cancer, with histologic analysis as the reference standard.

MATERIALS AND METHODS

This study was institutional review board approved, and patient informed consent was waived. A commercially available CAD system was applied to initial and follow-up digital mammograms obtained in 93 women with breast cancer (mean age, 52 years; age range, 32-81 years). The mean interval between mammographic examinations was 23 days (range, 7-58 days). There were 119 visible lesion components (70 masses, 49 microcalcifications). Sensitivity, false-positive mark rate, and reproducibility of the CAD system were evaluated for both sets of mammograms with the t test.

RESULTS

Sensitivities of the CAD system at initial and follow-up digital mammography were 91% and 89%, respectively, for detection of masses. Sensitivity of the CAD system for detection of microcalcifications was 100% at both initial and follow-up digital mammography. Overall false-positive mark rates were 0.29 per image and 0.27 per image at initial and follow-up digital mammography, respectively. When craniocaudal and mediolateral oblique views were considered separately, sensitivities were 76% and 75%, respectively, for masses and 96% and 92%, respectively, for microcalcifications. The reproducibility of CAD marks was 80% for true-positive masses, 92% for true-positive microcalcifications, 9% for false-positive masses, and 8% for false-positive microcalcifications (P < .001).

CONCLUSION

The sensitivity of the CAD system was consistently high for detection of breast cancer on initial and short-term follow-up digital mammograms. Reproducibility was significantly higher for true-positive CAD marks than for false-positive CAD marks.

SUPPLEMENTAL MATERIAL

http://radiology.rsnajnls.org/cgi/content/full/246/1/71/DC1.

摘要

目的

以组织学分析作为参考标准，回顾性评估应用于乳腺癌女性患者系列数字乳腺摄影的计算机辅助检测（CAD）系统的敏感性和可重复性。

材料与方法

本研究经机构审查委员会批准，且患者知情同意书被豁免。将一种商用CAD系统应用于93例乳腺癌女性患者（平均年龄52岁；年龄范围32 - 81岁）的初始及随访数字乳腺摄影。乳腺摄影检查的平均间隔时间为23天（范围7 - 58天）。共有119个可见病变成分（70个肿块，49个微钙化）。采用t检验对两组乳腺摄影图像评估CAD系统的敏感性、假阳性标记率和可重复性。

结果

CAD系统在初始及随访数字乳腺摄影中检测肿块的敏感性分别为91%和89%。CAD系统在初始及随访数字乳腺摄影中检测微钙化的敏感性均为100%。初始及随访数字乳腺摄影时总的假阳性标记率分别为每张图像0.29个和0.27个。当分别考虑头尾位和内外斜位视图时，肿块的敏感性分别为76%和75%，微钙化的敏感性分别为96%和92%。CAD标记的可重复性对于真阳性肿块为80%，对于真阳性微钙化为92%，对于假阳性肿块为9%，对于假阳性微钙化为8%（P <.001）。