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刺钩纽虫——吡啶神经毒素的新来源。

Hoplonemertine worms -- a new source of pyridine neurotoxins.

作者信息

Kem W R, Scott K N, Duncan J H

出版信息

Experientia. 1976 Jun 15;32(6):684-6. doi: 10.1007/BF01919831.

DOI:10.1007/BF01919831
PMID:181266
Abstract

Two pyridine bases were isolated from the marine hoplonemertine Amphiporus angulatus (Fabricius) and identified by mass and PMR-spectroscopy as 2, 3'-bipyridyl and 3, 2'; 3', 2"; 4", 3"'-tetrapyridyl (Nemertelline). Nemertelline, the first tetrapyridyl natural product to be reported, shows a structural resemblance to the tobacco constituent nicotelline. The crustacean toxicity of 2, 3' -bipyridyl is very similar to that of nicotine, but its mammalian toxicity is negligible.

摘要

从海洋刺胞纽虫角形歧肠纽虫(Fabricius)中分离出两种吡啶碱,并通过质谱和核磁共振光谱鉴定为2, 3'-联吡啶和3, 2'; 3', 2"; 4", 3"'-四吡啶(纽虫碱)。纽虫碱是首个被报道的四吡啶天然产物,其结构与烟草成分烟碱相似。2, 3'-联吡啶对甲壳类动物的毒性与尼古丁非常相似,但其对哺乳动物的毒性可忽略不计。

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本文引用的文献

1
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Br J Pharmacol Chemother. 1962 Jun;18(3):543-9. doi: 10.1111/j.1476-5381.1962.tb01173.x.
2
Biosynthesis of the nicotiana alkaloids. XIV. The incorporation of delta 1-piperideine-6-14C into the piperidine ring of anabasine.烟草生物碱的生物合成。十四。Δ¹-哌啶-6-¹⁴C掺入新烟草碱的哌啶环中。
J Am Chem Soc. 1969 Mar 26;91(7):1697-700. doi: 10.1021/ja01035a018.
3
A study of the occurrence of anabaseine in Paranemertes and other nemertines.
Toxins (Basel). 2023 Nov 12;15(11):650. doi: 10.3390/toxins15110650.
4
Discovery of the Nicotinic Receptor Toxin Anabaseine in a Nemertean.在纽形动物中发现烟碱型受体毒素阿那巴碱。
Toxins (Basel). 2023 Jan 5;15(1):46. doi: 10.3390/toxins15010046.
5
Pyridine alkaloids with activity in the central nervous system.在中枢神经系统中具有活性的吡啶生物碱。
Bioorg Med Chem. 2020 Dec 15;28(24):115820. doi: 10.1016/j.bmc.2020.115820. Epub 2020 Oct 16.
6
A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine.两种异构烟碱型受体激动剂的药理学比较:海洋毒素异石房蛤毒素和烟草生物碱石房蛤毒素。
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The Toxins of Nemertean Worms.纽形动物的毒素。
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