Dumont J, Liabeuf A, Henle W, Feingold N, Kourilsky F M
Int J Cancer. 1976 Jul 15;18(1):14-23. doi: 10.1002/ijc.2910180104.
Antibody titers to Epstein-Barr virus (EBV)-related antigens, i.e. viral capsid antigen (VCA), the D and R components of the early antigen (EA) complex and the EBV-associated nuclear antigen (EBNA), were determined in a series of 86 patients with non-Hodgkin lymphomas and in 150 matched control subjects. The lymphoma patients belonged to four histological groups: diffuse, nodular, hyperbasophilic malignant lymphoma (HML) and unclassified. The EBV-related serological data were compared to the incidence of antibodies to other herpes viruses, i.e. cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella zoster virus (VZV), and correlated with immune disorders, which are particularly frequent in the HML type of lymphoma. The results revealed a significantly higher incidence of anti-EA-D titers in lymphoma patients and slight but significant increases in the geometric mean anti-VCA titers in the HML and unclassified group of patients. These elevated anti-EBV titers in patients were not associated with an increase in titres of antibodies to other herpes viruses. They did not correlate with the signs of immune deficiency observed or with the incidence of auto-antibodies.
在86例非霍奇金淋巴瘤患者及150例匹配的对照受试者中，测定了针对爱泼斯坦-巴尔病毒（EBV）相关抗原，即病毒衣壳抗原（VCA）、早期抗原（EA）复合物的D和R成分以及EBV相关核抗原（EBNA）的抗体滴度。淋巴瘤患者分为四个组织学组：弥漫性、结节性、嗜碱性恶性淋巴瘤（HML）和未分类。将EBV相关的血清学数据与针对其他疱疹病毒，即巨细胞病毒（CMV）、单纯疱疹病毒（HSV）和水痘带状疱疹病毒（VZV）的抗体发生率进行比较，并与免疫紊乱相关，免疫紊乱在HML型淋巴瘤中尤为常见。结果显示，淋巴瘤患者中抗EA-D滴度的发生率显著更高，在HML和未分类患者组中，几何平均抗VCA滴度略有但显著升高。患者中这些升高的抗EBV滴度与针对其他疱疹病毒的抗体滴度增加无关。它们与观察到的免疫缺陷体征或自身抗体的发生率无关。
