Cronin M T, Dearden J C, Dobbs A J
School of Health Sciences, Liverpool Polytechnic, United Kingdom.
Sci Total Environ. 1991 Dec;109-110:431-9. doi: 10.1016/0048-9697(91)90198-n.
This study investigated the relationships between the toxicities of common organic pollutants to the fathead minnow (Pimephales promelas), to Daphnia magna, to Tetrahymena pyriformis and in the Microtox test, which uses the luminescent bacterium Photobacterium phosphoreum. The toxicity data were compiled from the literature, with the exception of 40 experimentally determined Microtox data. Encouraging correlations are seen, indicating significant relationships between fish toxicities and those to lower organisms. When the toxicities of individual chemical classes are studied, further improvement is often seen in the correlations. Analysis of significant outliers from the inter-species relationships has led to the suggestion that the fathead minnow may be more susceptible to chemicals that are metabolised to reactive intermediates (such as the aldehydes). The fish may, however, be less susceptible to other chemical classes such as ketones and alcohols.
本研究调查了常见有机污染物对黑头呆鱼（Pimephales promelas）、大型溞、梨形四膜虫的毒性，以及在使用发光细菌费氏弧菌的微毒性测试中的毒性之间的关系。毒性数据除40个通过实验测定的微毒性数据外，均从文献中汇编而来。可以看到令人鼓舞的相关性，表明鱼类毒性与对低等生物的毒性之间存在显著关系。当研究个别化学类别的毒性时，相关性往往会进一步提高。对种间关系中显著异常值的分析表明，黑头呆鱼可能对代谢为活性中间体的化学物质（如醛类）更敏感。然而，这种鱼可能对其他化学类别（如酮类和醇类）不太敏感。
