Waldmann Herman
Sir William Dunn School of Pathology, Oxford University, Oxford, UK.
Immunology. 2008 Jan;123(1):11-2. doi: 10.1111/j.1365-2567.2007.02776.x.
The concept of T-cell mediated suppression evolved more than 30 years ago. At that time it spawned many claims that have not stood the test of time. The rediscovery of suppression phenomena and regulatory T cells over the past 15 years created schizophrenic responses amongst immunologists. Some claimed that the new proponents of suppression were, once again, bringing immunology into disrepute, whilst others have embraced the field with great enthusiasm and novel approaches to clarification. Without faithful repetition of the "old" experiments, it is difficult to establish what was right and what was wrong. Nevertheless, immunologists must now accept that a good number of the old claims were overstated, and reflected poor scientific discipline. "I speak not to disprove what Brutus spoke, But here I am to speak what I do know" Shakespeare. Julius Caesar Act 3, Scene 2.
T细胞介导的抑制概念早在30多年前就已出现。当时引发了许多经不起时间考验的论断。在过去15年里，抑制现象和调节性T细胞的重新发现，在免疫学家中引发了自相矛盾的反应。一些人声称，抑制的新支持者再次让免疫学蒙羞，而另一些人则满怀热情地投身该领域，并采用新颖的方法来进行阐释。如果不忠实重复那些“旧”实验，就很难确定哪些是正确的，哪些是错误的。然而，免疫学家现在必须承认，许多旧的论断都被夸大了，反映出糟糕的科学规范。“我不是要反驳布鲁图斯的话，而是要说出我所知道的事实” 莎士比亚。《尤利乌斯·恺撒》第三幕第二场
