Basten Antony, Fazekas de St Groth Barbara
Garvan Institute of Medical Research, Sydney, NSW, Australia.
Immunology. 2008 Jan;123(1):33-9. doi: 10.1111/j.1365-2567.2007.02772.x.
The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. Cannon to right of them, Cannon to left of them, Cannon in front of them Volley'd and thunder'd Storm'd at with shot and shell, Boldly they rode and well, Into the jaws of Death, Into the mouth of Hell, Rode the six hundred (suppressionists). (Adapted from The Charge of the Light Brigade, Alfred, Lord Tennyson)
自20世纪60年代两个细胞系统被描绘以来，T细胞依赖性免疫反应调节的概念一直是免疫学思想的核心原则。事实上，T细胞依赖性抑制在MHC限制之前就已被发现。回顾最初一波抑制的数据时，有趣的是不仅要思考20世纪80年代抑制性T细胞的衰落，还要思考它们在过去十年中同样戏剧性地重新获得认可。希望它们的复兴将得到坚实的机制数据的支持，这些数据将巩固它们在我们当前和未来对免疫系统理解中的核心地位。 加农炮在他们右边，加农炮在他们左边，加农炮在他们面前 排炮轰鸣，雷电交加 枪林弹雨向他们袭来， 他们勇敢地骑行，技艺娴熟， 冲进死亡之口， 冲进地狱之嘴， 骑行着的六百勇士（抑制论者）。（改编自阿尔弗雷德·丁尼生男爵的《轻骑兵进击》）
