Langewouters A M G, van Erp P E J, de Jong E M G J, van de Kerkhof P C M
Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Arch Dermatol Res. 2008 Mar;300(3):107-13. doi: 10.1007/s00403-007-0819-9. Epub 2007 Dec 19.
In several studies peripheral blood T-cells have been quantified, yet few data are available on lymphocyte subsets in moderate-to-severe psoriasis (in terms of extent and activity of lesions) versus mild psoriasis. The objective is to compare lymphocyte subsets in peripheral blood of patients with moderate-to-severe disease (PASI-score > or =12) to patients with mild disease (PASI-score <12) and to healthy subjects. By means of flow cytometry method, lymphocytes in peripheral blood of 27 patients with psoriasis and 10 healthy controls were characterized. The absolute number of total lymphocytes was markedly decreased in patients with moderate-to-severe psoriasis as compared to patients with mild disease and normal subjects. Cellcounts of all analysed subsets were found to be increased in more severe psoriasis, except for CD8+CD45RO+ cells. The under-representation of CD8+CD45RO+ cells is compatible with the dynamics of acquired immunity, which requires a time log after the relapse of the lesions to differentiate from CD45RA+ naive cells.
在多项研究中，外周血T细胞已被定量，但关于中重度银屑病（根据皮损范围和活动度）与轻度银屑病患者淋巴细胞亚群的数据却很少。目的是比较中重度疾病患者（银屑病面积和严重程度指数评分≥12）、轻度疾病患者（银屑病面积和严重程度指数评分＜12）以及健康受试者外周血中的淋巴细胞亚群。通过流式细胞术方法，对27例银屑病患者和10名健康对照者外周血中的淋巴细胞进行了特征分析。与轻度疾病患者和正常受试者相比，中重度银屑病患者的总淋巴细胞绝对数量明显减少。除CD8 + CD45RO +细胞外，所有分析亚群的细胞计数在更严重的银屑病中均增加。CD8 + CD45RO +细胞的数量不足与获得性免疫的动态变化相符，这需要在皮损复发后经过一段时间才能从CD45RA +幼稚细胞分化而来。
