Goldberg M, Lacerda-Pinheiro S, Priam F, Jegat N, Six N, Bonnefoix M, Septier D, Chaussain-Miller C, Veis A, Denbesten P, Poliard A
Laboratoire de Réparation et de Remodelages Oro-Faciaux (EA 2496), Université Paris Descartes, Montrouge, France.
Clin Oral Investig. 2008 Jun;12(2):109-12. doi: 10.1007/s00784-007-0172-6. Epub 2007 Dec 22.
This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.
本综述总结了我们小组进行的体内实验，这些实验是将生物活性分子（基质细胞分子）植入大鼠上颌第一磨牙或大鼠和小鼠下颌切牙的暴露牙髓后开展的。我们描述了参与修复性牙本质形成的细胞的募集、增殖和终末分化级联反应。克隆的永生化成牙本质细胞祖细胞也被植入切牙，并进行了体外研究，旨在揭示从未分化祖细胞到完全分化的极化细胞的信号通路。这些实验方法共同为可控的牙本质再生过程和修复铺平了道路。
